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2-butoxyethanol 111-76-2 OSHA No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential ... Misty(R) Disinfectant Foam Cleaner Version 1.1 Revision Date 05/31/2015 Print Date 04/07/2016 3 / 12 Wash contaminated clothing before re-use. NTP No component of this product present at levels greater than or equal to 0.1% is identified … It acts as a surfactant in domestic and industrial products. 2-butoxyethanol; ethyleneglycol monobutyl ether; butyl cellosolve CAD - Chemical Agents Directive, Art. 2-butoxyethanol has adverse effects on the CNS (e.g. 2-Butoxyethanol is also used in medicines and medical devices currently registered on the ARTG. Michael E. Peterson DVM, MS, Patricia A. Talcott MS, DVM, PhD, DAVBT, in Small Animal Toxicology (Second Edition), 2006. An application was submitted by the Australian Pesticides and Veterinary Medicines Authority (APVMA) to amend the Poisons Standard with respect to 2-butoxyethanol. However, the major metabolite of 2-BE, butoxyacetic acid, produces marked swelling and lysis of erythrocytes in vitro (Corley et al., 2005). Diethylene glycol is used in numerous products including solvents and brake fluids. 2. In a study of topical exposure of mice to 2-BE, Singh et al. Like other members of its family, it’s derived from crude oil, and can significantly harm your animal companion if ingested or inhaled over long periods. Intraperitoneal administration of ferric iron-ATP (FeATP) has been studied in an animal model. Skin and eye irritation consistent with Schedule 6. The National Institute for Occupational Safety and Health evaluated the acute effects of inhalation of dispersant in rats on the respiratory, cardiovascular, and nervous systems as well as the immune effects of dermal exposure. The delegate's decision was based on the fact that hexyloxyethanol's toxicity profile was different from the chemical class ethylene glycol monoalkyl ethers. Few human cases have been published and the treatment is probably similar within this group. However, exposure to compounds in the propylene series was not lethal to rodents even at nearly saturated concentrations. This Hazardous item is a Limited Quantity Hazardous item. It is an active component of fracturing fluids, drilling stabilizers and oil slick dispersants. Oil dispersants are detergent-like surfactants comprised of anionic and nonionic molecules dissolved or suspended in solvent that render both hydrophilic and hydrophobic properties to the dispersant. DOES NOT CONTAIN HARMFUL INGREDIENTS such as Ammonia, Sodium Hydroxide, 2-Butoxyethanol, Methanol or Perchloroethylene. The monoalkyl ethylene glycol ethers have been shown to possess a wide spectrum of biological activity, with some variation in the range of effects and potency among the individual compounds. The primary skin irritation study with the formulated product revealed slight irritation that resolved completely by 72 hours following administration of the test material. Toxicity of 2-butoxyethanol is mitigated when formulated as a plant grown regulator, allowing a higher percentage cut off. Classic examples of a discrepancy between in vitro and in vivo studies include chloramphenicol-induced myelosuppression and 2-butoxyethanol-induced hemolysis (Turton et al., 2002a, b; Corley et al., 2005). EGME was teratogenic, embryotoxic, and fetotoxic in pregnant animals. Some types of glycol ethers found in cleaning products are 2 Butoxyethanol, a lung irritant and possible carcinogen that may cause liver damage, and 4-t-nonylphenol, an … Based on limited data from case reports and one laboratory study, similar acute effects, including haemolytic and CNS effects are observed in humans and rats exposed to 2-butoxyethanol, although the effects are observed at much higher exposure concentrations in humans than in rats. Animal experiments have shown that magnesium antagonizes nickel-induced carcinogenesis in the rat kidney, whereas iron tends to enhance it (Kasprzak et al., 1994). The testicular effects have been observed in mice, rats, rabbits, and dogs, and the hematological effects have been observed in mice, rats, rabbits, cats, dogs, and man. In cell experiments, addition of catalase, which can increase Fe2+ concentrations, further increased the plasmid-induced DNA damage; on the other hand, diethylenetriaminepentaacetic acid (an iron chelator) significantly inhibited DNA damage. See a list of cleaners that kill coronavirus. Windex Original Glass Cleaner is not a disinfectant and it will not kill germs. A study conducted in 1989 tested a series of 2-butoxyethanol concentrations (10, 20, 30, 70 and 100%) for eye irritation. However, the majority of the 1 800 000 US gallons (6800 m3) of dispersants which had been used; mostly COREXIT 9500 was sprayed from airplanes or surface craft onto the oil slicks. With COVID-19 (coronavirus) now a global pandemic and spreading throughout the United States, many people are wondering which cleaners kill coronavirus.Specifically, do lysol wipes or … Table 22.2. 2-Butoxyethanol was identified as a causal agent in the health problems experienced by cleanup workers after the 1989 Exxon Valdez oil spill. Acute toxicity Product: Oxidative DNA damage increased in Syrian Hamster Embryo cells after treatment with ferrous sulfate. The metabolic acidosis was due to the butylglycol metabolite, butoxy acetic acid, and to lactate. These compounds enhance the dispersion of oil by reducing the oil/water interfacial tension and facilitating the formation of small mixed oil surfactant micelles within the water column; thus preventing the oil slick from reaching the shore. It was agreed that Schedule 6 was appropriate due to the formulation, handling and use of cleaning products containing 2-butoxyethanol which may give rise to a risk of adverse health effects and that 2-butoxyethanol is considered acutely more toxic that most glycol ethers. 2-butoxyethanol has low to moderate acute toxicity via oral, dermal and inhalation routes, and severe skin and eye irritancy. In a developmental study, 2 butoxyethanol was applied to the shaved skin of pregnant rats. Although ethylene glycol toxicity is uncommon, when it does occur, it can have a high morbidity or mortality. Glycol is a chemical compound that is diol containing two hydroxyl groups. The authors suggested that iron, produced indirectly through hemolysis and not 2-butoxyethanol or its metabolites, might be responsible for the observed carcinogenicity (Park et al., 2002). The applicant's reasons for the proposal were: 2-Butoxyethanol is in Schedule 6, Appendix E and Appendix F of the Poisons Standard as follows: 2-BUTOXYETHANOL and its ACETATES except in preparations containing 10 per cent or less of such substances. Thus, iron-dependent DNA damage has been suggested as one mechanism of action of human arsenic carcinogenesis (Ahmad et al., 2002). In rats, EGME and its metabolite have also been reported to cause thymic involution in the absence of effects on body weight or spleen weight, reduced response to T cell mitogens, depressed production of interleukin-2, and altered response to primary antibody plaque-forming cells. Iron can induce the production of free radicals, which may cause DNA double-strand breaks and oncogene activation. 2-Butoxyethanol acetate is widely used as a slow-evaporating solvent for lacquers, varnishes, epoxy resins, and enamels. The PSC therefore decided to include preparations containing 5 per cent or more ethylene glycol monoalkyl ethers and their acetates in Schedule 6. However, there are other forms of leukemia that have weak correlations with exposure to alkylating agents (Bloom and Brandt, 1997). 2-Butoxyethanol. In November 2014, the ACCS considered a proposal to create separate entries for a number of ethylene glycol monoalkyl ethers and their acetates, including 2-butoxyethanol. The Novel Human Corona Virus that originated in Wuhan China now called SARS-CoV-2 the cause of COVID-19 has been declared a pandemic. 2-Butoxyethanol is used in many industries. GUNNAR F. NORDBERG, ... BRUCE A. FOWLER, in Handbook on the Toxicology of Metals (Third Edition), 2007. It is a glycol ether solvent that helps break down dirt and oil. Hazardous materials are non-returnable. Ammonia Exposed test subjects (rats) developed tolerance to 2-butoxyethanol (haemolytic effects). Despite numerous cellular defense mechanisms such as antioxidant enzymes and low molecular weight antioxidants such as GSH, hemolysis may result if these mechanisms are overwhelmed in red blood cells. Overexposure can cause anemia, intoxication and irritation of the eyes and nose. 2-Butoxyethanol has haemolytic effects. The results of in vitro studies indicate that human red blood cells are not as sensitive as rat red blood cells to the haemolytic effects of 2-butoxyethanol and 2-butoxyacetic acid and also that red blood cells are more sensitive to haemolysis by 2-butoxyacetic acid than to haemolysis by 2-butoxyethanol. Another major mechanism of toxicity seen with many compounds involves the formation of reactive oxygen species (ROS), including superoxide anion, hydrogen peroxide and hydroxyl radical. Butylglycol poisoning has been reported following the suicidal ingestion of a window-cleaning agent containing butylglycol (ethylene glycol monobutyl ether) and ethanol [73]. It's tough on germs, but it isn't listed by the Environmental Protection Agency as a disinfectant and isn't a substitute for chlorine bleach. The most sensitive toxicological end point is the destruction of red blood cells (haemolysis). Based on these case reports and overall theoretical considerations, it would be reasonable to treat these poisonings like those with ethylene glycol poisoning. Butoxyethanol is an excipient ingredient in 5 products on the Australian Register of Therapeutic Goods (ARTG) . Until this is complete we can not claim that it is a disinfectant in Canada. You may recognize it by its sweet, slightly floral scent. Other less frequently encountered glycols include diethylene glycol, propylene glycol, ethylene glycol monobutyl ether (EGBE), and ethylene glycol monomethyl ether (EGME). Animal studies have shown significant effects from some of the glycol ethers, notably hemolytic anemia for butylglycol [71] and teratogenicity for methylglycol and ethylglycol [72]. Experiments on hamsters have shown that estrogen treatment increased the non-heme iron in liver of both high and low iron treatment groups and in kidney of the hamsters on the low-iron diet. 2-Butoxyethanol Petroleum Uses This product is an essential component of fracturing fluids, drilling stabilizers, and oil slick dispersants for water-based and oil-based hydraulic fracturing. It also acts as a deodorizer and cuts grease. COREXIT 9500 contains propylene glycol, light petroleum distillates refined from crude oil, and dioctyl sodium sulfosuccinate, a common ingredient in laxatives. D. Jacobsen, K.E. 2-Butoxyethanol caused 20% mortality in treated dams but had no effects on the offspring. The delegate also decided to create new Appendices E, F and I entries specifically for hexyloxyethanol. Used in industry for degreasing and detergent applications.2-n-Butoxyethanol is used in the industry for degreasing and detergent applications. No public submissions were received before the first closing date in response to an invitation published on 12 April 2018 under regulation 42ZCZK of the Regulations. In general, the hemolytic effects appear to increase with the size of the alkoxy group. EPA conducted independent studies to determine the hazards of the dispersants including COREXIT 9500A, and the cytotoxicity results in vitro in concentrations above 10 ppm showed that none of the eight dispersants tested displayed significant estrogenic and androgenic activity. The APVMA recently evaluated acute toxicity data for a product containing approximately 20% 2-butoxyethanol (final concentration was 175 g/L). They both had an uneventful recovery following treatment with bicarbonate and ethanol. The ingested dose of butylglycol was about 25–30 g giving a blood level of 0.43 g/l upon admission. The ecological and human health impacts of the Deepwater Horizon oil blowout may differ from the previous oil spills such as the Exxon Valdez because of the depth at which the oil leak occurred, the large volume of oil released, and the unprecedented volume of dispersant (COREXIT 9500 and 9527) used. Beware: Your Green Cleaning Product May Be Toxic. The concentration in the medicine must be no more than 0.1%. However, the Draize scores indicate that at those concentrations, it is practically non-irritating (scores of 1/110 and 2/110 at 10% and 20%, respectively) (Kennah et al., 1989). In August 1995, the NDPSC considered a proposal to either exempt 2-butoxyethanol from scheduling or create a separate entry for 2-butoxyethanol in Schedule 5. Inhalation exposure to high concentrations of compounds in the ethylene series can cause lethality. However, the committee agreed to create a new separate entry in Schedule 6 for 2-butoxyethanol and its acetates with an exception for preparations containing 10 per cent or less. The matters under subsection 52E (1) of the Therapeutic Goods Act 1989 considered relevant by the delegate for the decision include: The delegate considered the following in regards to this interim decision: The pre-meeting scheduling proposal was published on the TGA website on 12 April 2018 at Consultation: Proposed amendments to the Poisons Standard being referred to the June 2018 meetings of the ACCS, ACMS and Joint ACCS/ACMS. Rodney R. Dietert, in Endocrine Disruption and Human Health, 2015. EGME has been reported to affect conditioned avoidance behavior in trained rats, and PGME has been reported to cause central nervous system (CNS) depression. It is a colorless liquid with a sweet, ether-like odour. In COREXIT 9500 the toxic 2-butoxyethanol was replaced with light petroleum distillate. Risk: 2-Butoxyethanol has haemolytic and Central Nervous System (CNS) effects, low to moderate acute toxicity via oral, dermal and inhalation routes, and severe skin and eye irritancy. In November 1984, the Poisons Schedule (Standing) Committee (PSC) considered the scheduling of ethylene glycol monoalkyl ethers and their acetates. In November 2013, based on the ACCS advice, the delegate created a separate schedule entry for hexyloxyethanol with a cut-off level to exempt from scheduling for preparations containing 10 per cent of less of hexyloxyethanol. There was an indication of ethanol inhibition of butylglycol metabolism and of an effect of hemodialysis in this patient. In experimental studies, 2-butoxyethanol increased liver tumors in B6C3F1mice after chronic exposure. 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